| Solvang Brewing Company - Lompoc | 234 N H St | Lompoc | California | 93436-6022 | United States | brewpub | |
| Sonoma Grille | 165 W Napa St | Sonoma | California | 95476-6626 | United States | brewpub | |
| Sonoma Springs Brewing Co | 19449 Riverside Dr Ste 101 | Sonoma | California | 95476-6357 | United States | micro | |
| Sons of Liberty Aleworks | 1780 Town and Country Dr Ste 101 | Norco | California | 92860-3618 | United States | micro | |
| Soquel Fermentation Project | | Los Gatos | California | 95033 | United States | micro | |
| South Bay Brewco | 930 McLaughlin Ave | San Jose | California | 95122-2611 | United States | contract | |
| South Gate Brewing Co | 40233 Enterprise Dr | Oakhurst | California | 93644-8839 | United States | brewpub | |
| South Lake Brewing Company | 1920 Lake Tahoe Blvd | South Lake Tahoe | California | 96150-6307 | United States | micro | |
| South Park Brewing | 1517 30th St | San Diego | California | 92102-1503 | United States | brewpub | |
| Southern Pacific Brewing | 620 Treat Ave | San Francisco | California | 94110-2016 | United States | brewpub | |
| Southpaw BBQ & Southern Cooking | 2170 Mission St | San Francisco | California | 94110-1247 | United States | brewpub | |
| Speakeasy Ales and Lagers | 1195 Evans Ave | San Francisco | California | 94124-1704 | United States | micro | |
| SR 76 Beerworks | 777 HARRAHS RINCON WAY | Valley Center | California | 92082 | United States | closed | |
| St Clair Brown Winery & Brewery | 816 Vallejo St | Napa | California | 94559 | United States | micro | |
| St. Florian's Brewery | 7704 Bell Rd Ste A | Windsor | California | 95492-8518 | United States | closed | |
| Stadium Brewing Co | 26731 Aliso Creek Rd Ste C | Aliso Viejo | California | 92656-4811 | United States | brewpub | |
| Stadium Pizza - Murrieta | 32278 Clinton Keith Rd Ste 101 | Wildomar | California | 92595-7314 | United States | brewpub | |
| Stadium Pizza Main ST | 169 N Main St | Lake Elsinore | California | 92530-4005 | United States | brewpub | |
| Standard Deviant Brewing | 280 14th St | San Francisco | California | 94103-2420 | United States | micro | |
| Star B Ranch | | Ramona | California | 92065-6714 | United States | planning | |
| Stash Brewing Co | 3782 Winding Creek Ln | Garden Valley | California | 95633-9773 | United States | closed | |
| State Brewing Co LLC | 1237 W 134th St Ste 2 | Gardena | California | 90247-1962 | United States | closed | |
| State Room Brewery | 1132 4th St | San Rafael | California | 94901-3007 | United States | brewpub | |
| Stateline Brewery | 4118 Lake Tahoe Blvd Ste 1 | South Lake Tahoe | California | 96150-6990 | United States | brewpub | |
| Steady Brewing | 2936 Clark Ave | Long Beach | California | 90815 | United States | micro | |
| Steel Bonnet Brewing Co | 20 Victor Sq Ste B | Scotts Valley | California | 95066-3518 | United States | micro | |
| Steele and Hops Public House | 1901 Mendocino Ave | Santa Rosa | California | 95401 | United States | brewpub | |
| Steelhead Brewing Co - Burlingame Station | 333 California Dr | Burlingame | California | 94010-4114 | United States | brewpub | |
| Stereo Brewing Co | 950 S Via Rodeo | Placentia | California | 92870-6775 | United States | micro | |
| Stone Brewing Co | 2120 Harmony Grove Rd | Escondido | California | 92029-2053 | United States | regional | |
| Stone Brewing Napa | 920-930 Third Street | Napa | California | 94559 | United States | closed | |
| Stone Brewing World Bistro & Gardens- Liberty Station | 2816 Historic Decatur Rd Ste 116 | San Diego | California | 92106-6164 | United States | brewpub | |
| Stone Church Brewing | 2785 Cabot Dr Ste 160 | Corona | California | 92883-7388 | United States | micro | |
| Storytellers Brewery and Meet House, LLC | | Corona | California | 92880-1798 | United States | planning | |
| Stover Brewing | | San Diego | California | 92124-1426 | United States | planning | |
| Strand Brewing Co | 2201 Dominguez St | Torrance | California | 90501-1418 | United States | micro | |
| Strike Brewing Co | 2099 S 10th St Unit 30 | San Jose | California | 95112-4116 | United States | micro | |
| Strum Brewing Company | 235 S Campus Ave | Ontario | California | 91761-1736 | United States | micro | |
| Stumblefoot Brewing | 1784 La Costa Meadows Dr Ste 103 | San Marcos | California | 92078-5174 | United States | micro | |
| Stumptown Brewery | 15045 River Rd | Guerneville | California | 95446-8043 | United States | brewpub | |
| Sudwerk Brewing Co | 2001 2nd St | Davis | California | 95618-5474 | United States | micro | |
| Sufferfest Beer Company | 1770 UNION STREET | San Francisco | California | 94123-3404 | United States | proprietor | |
| Sugar Monkey Brewing & Social Club | 339 Indiana St | El Segundo | California | 90245 | United States | micro | |
| Sundowner Brewing Co. | 30961 Agoura Rd Ste 321 | Westlake Village | California | 91361-5686 | United States | micro | |
| Sunset Reservoir Brewing Company | 1735 Noriega St | San Francisco | California | 94122-4307 | United States | brewpub | |
| Super Owl Brewing | 1260 Lake Blvd Ste 121 | Davis | California | 95616-5669 | United States | micro | |
| Surf Brewery | 4561 Market St Ste A | Ventura | California | 93003-6483 | United States | closed | |
| Surfridge Brewing Company | | El Segundo | California | 90245-4209 | United States | planning | |
| Sutter Buttes Brewing | 421 Center St | Yuba City | California | 95991-4505 | United States | brewpub | |
| Syncopated Brewing Co | 3671 Industry Ave Ste C1 | Lakewood | California | 90712-4155 | United States | micro | |